Synlett, Table of Contents Synlett DOI: 10.1055/a-2726-4670 Letter Published as part of the Special Issue dedicated to Prof. S. Chandrasekaran on his 80th birthday Weak Coordination-Assisted Cobalt(III)-Catalyzed Regioselective Alkenylation of Indolines with Allenes Authors Author Affiliations Mainak Koner 1 Department of Chemistry, Indian Institute of Technology Madras, Chennai, India (Ringgold ID: RIN37268) Shabbir Ahmed Khan 1 Department of Chemistry, Indian Institute of Technology Madras, Chennai, India (Ringgold ID: RIN37268) Mahiuddin Baidya 1 Department of Chemistry, Indian Institute of Technology Madras, Chennai, India (Ringgold ID: RIN37268) Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Dedication On the occasion of Prof. S. Chandrasekaran’s 80th birthday. Abstract A cobalt(III)-catalyzed regioselective coupling of indolines with allenes is reported to access C7-alkenyl indolines in good to high yields. The method features weakly coordinating-group assistance, broad functional-group tolerance, including pharmacophores, scalability, and a reversible C–H activation step. Keywords KeywordsCobalt - Allenes - Indolines - C–H alkenylation Full Text References References For reviews, see: 1a Giri R, Shi BF, Engle KM, Maugel N, Yu JQ. Chem Soc Rev 2009; 38: 3242 1b Gutekunst WR, Baran PS. Chem Soc Rev 2011; 40: 1976 1c Abrams DJ, Provencher PA, Sorensen EJ. Chem Soc Rev 2018; 47: 8925 1d Sinha SK, Ghosh P, Jain S. et al. Chem Soc Rev 2023; 52: 7461 For reviews, see: 2a Gandeepan P, Müller T. et al. Chem Rev 2019; 119: 2192 2b Carvalho RL, De Miranda AS, Nunes MP, Gomes RS, Jardim GAM, Da Silva EN. Beilstein J Org Chem 2021; 17: 1849 2c Mandal R, Garai B, Sundararaju B. ACS Catal 2022; 12: 3452 2d Xio M, Li W, Jiang D, Cheng LJ. CCS Chem 2024; 6: 537 2e Guo J, Cheng Z, Chen J, Chen X, Lu Z. Acc Chem Res 2021; 54: 2701 2f Chen J, Guo J, Lu Z. Chin J Chem 2018; 36: 1075 For reviews, see: 3a Hashmi ASK. Angew Chem Int Ed 2000; 39: 3590 3b Yu S, Ma S. Angew Chem Int Ed 2012; 51: 3074 3c Santhoshkumar R, Cheng CH. Asian J Org Chem 2018; 7: 1151 3d Yang B, Qiu Y, Bäckvall JE. Acc Chem Res 2018; 51: 1520 3e Deng SM, Zhao YX, Wang C. Tetrahedron Chem 2023; 8: 100049 4a Thrimurtulu N, Dey A, Maiti D, Volla CMR. Angew Chem Int Ed 2016; 55: 12361 4b Nakanowatari S, Mei R, Feldt M, Ackermann L. ACS Catal 2017; 7: 2511 4c Han XL, Lin PP, Li Q. Chin Chem Lett 2019; 30: 1495 4d Shukla RK, Nair AM, Volla CMR. Synlett 2021; 32: 1169 4e Shukla RK, Singh A, Shetty R, Volla CMR. Adv Synth Catal 2025; 367: e202401400 and references cited therein 4f Koner M, Ballav N, Varma AJ, Ghosh S, Mondal T, Kuniyil R, Baidya M. Chem Sci 2025; 16: 19296 4g Meyer TH, Oliveira JCA, Sau SC, Ang NWJ, Ackermann L. ACS Catal 2018; 8: 9140 4h Lin Y, Münchow TV, Ackermenn L. ACS Catal 2023; 13: 9713 5a Gangadhararao G, Kotikalapudi R, Reddy MN, Kumara Swamy KC. Beilstein J Org Chem 2014; 10: 996 5b Kumara Swamy KC, Anitha M, Gangadhararao G, Rama Suresh R. Pure Appl Chem 2017; 89: 367 5c Anitha M, Kumara Swamy KC. Org Biomol Chem 2019; 17: 5736 5d Chowdhury D, Koner M, Ghosh S, Baidya M. Org Lett 2022; 24: 3604 5e Xie ST, Wang ZH, Yang L. et al. Chin J Chem 2025; 43: 2385 6a Horsman GP, Zechel DL. Chem Rev 2017; 117: 5704 6b Finkbeiner P, Hehn JP, Gnamm C. J Med Chem 2020; 63: 7081 7a Bhattacharya T, Ghosh A, Maiti D. Chem Sci 2021; 12: 3857 7b Ghosh S, Patra K, Baidya M. Eur J Org Chem 2024; 27: e202301321 8 Chen J, Wei W-T, Li Z, Lu Z. Chem Soc Rev 2024; 53: 7566 Supplementary Material Supplementary Material Supplementary Material (PDF) (opens in new window)
